Istradefylline forty mg/day amplified peak stages and AUC of CYP3A4 substrates in medical trials. This impact wasn't noticed with istradefylline 20 mg/working day. Think about dose reduction of delicate CYP3A4 substrates. dronedarone will boost the degree or result of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraind